منابع مشابه
TRPM4 channel: a new player in urinary bladder smooth muscle function in rats.
The TRPM4 channel is a Ca(2+)-activated, monovalent cation-selective channel of the melastatin transient receptor potential (TRPM) family. The TRPM4 channel is implicated in the regulation of many cellular processes including the immune response, insulin secretion, and pressure-induced vasoconstriction of cerebral arteries. However, the expression and function of the TRPM4 channels in detrusor ...
متن کاملPharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle.
The contractile state of vascular smooth muscle cells is regulated by small changes in membrane potential that gate voltage-dependent calcium channels. The melastatin transient receptor potential (TRP) channel TRPM4 is a critical mediator of pressure-induced membrane depolarization and arterial constriction. A recent study shows that the tricyclic compound 9-phenanthrol inhibits TRPM4, but not ...
متن کاملChannels in Smooth Muscle Cells
The effects of sulfhydryl reduction/oxidation on the gating of large-conductance, Ca 2 1 -activated K 1 (maxi-K) channels were examined in excised patches from tracheal myocytes. Channel activity was modified by sulfhydryl redox agents applied to the cytosolic surface, but not the extracellular surface, of membrane patches. Sulfhydryl reducing agents dithiothreitol, b -mercaptoethanol, and GSH ...
متن کاملVascular Smooth Muscle Calcium Channels
Voltage-gated Ca 21 channels of the plasma membrane open in response to changes in cell membrane potential, providing an important pathway for regulated entry of extracellular Ca ions. Ca channels comprise a family of structurally related proteins displaying tissueand stage-specific expression. They are classified as either high voltage-activated (HVA) or low voltage-activated (LVA) and can be ...
متن کاملTRPC channels in smooth muscle cells.
Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently e...
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ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2013
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-013-1250-z